Lecture 1 - History of Neuroscience - Introduction - Part 1 Lecture 2 - History of Neuroscience - Introduction - Part 2 Lecture 3 - Factors that produce discoveries Lecture 4 - Importance of the 1950s in Neuroscience Lecture 5 - Advances in Molecular Biology (Genes to DNA) Lecture 6 - Discovery of the structure of the DNA Lecture 7 - How DNA works Lecture 8 - Molecular biology of the human brain Lecture 9 - Signaling molecule: The First growth Factor Lecture 10 - Nerve Growth Factor Lecture 11 - Organizing the Connections Lecture 12 - Axonal Transport Lecture 13 - Signaling molecules: The First Neurotransmitter in the brain Lecture 14 - The concept of Lock and Key Lecture 15 - The Soup vs Sparks Debate Lecture 16 - Intracellular Electrode, Neurotransmitter in the Brain, Dales Law Lecture 17 - Early evidence of Acetylcholine and Glutamate Lecture 18 - Early evidence of GABA and Serotonin Lecture 19 - Catecholamine and Hormones Lecture 20 - Second messengers and Hormones Lecture 21 - Pheromones Lecture 22 - Revolution in Cytology Lecture 23 - Synapse and the 'Neuronism vs Reticularism' debate Lecture 24 - Contributions by Rene Couteaux and George Koelle Lecture 25 - Chemical Synapse Lecture 26 - Synapse and the Neuromuscular Junction Lecture 27 - The Electrical Synapse and Myelin Lecture 28 - Physiology: The Action Potential - Part 1 Lecture 29 - Recording nerve impulses and single action potentials Lecture 30 - Recording from nerve and plant cells Lecture 31 - Recording Local circuits, Hodgkin and Huxely contributions - Part 1 Lecture 32 - Hodgkin and Huxely model - Part 2 and Kenneth Cole Contributions Lecture 33 - GHK equation and HH action potentials Lecture 34 - First Electrophysiological Evidence for Synaptic Transmission Lecture 35 - Bernard Katz Lecture 36 - End-Plate Potential and Synaptic Quanta Lecture 37 - Eccles and Spinal motor neuron Lecture 38 - Invertebrate simple systems: Aplysia Lecture 39 - Other studies of sensory responses Lecture 40 - Legacy of Golgi and Ramo`n y Cajal Lecture 41 - Dynamic polarization of Neuron Lecture 42 - Modern Research Lecture 43 - Synaptic Integration and Action Potential Initiation Lecture 44 - Active properties of dendrites Lecture 45 - Dendritic dominance Lecture 46 - Dendritic spines Lecture 47 - Rethinking the concept of Neuron Doctrine Lecture 48 - Muscle spindles Lecture 49 - Spinal cord pathways Lecture 50 - Retinal Processing Lecture 51 - Keffler Hartline Lecture 52 - Stephen Kuffler and Horace Barlow Lecture 53 - Expansion of the Reflex concept Lecture 54 - Central Pattern generators Lecture 55 - The cortical column Lecture 56 - Vernon Mountcastle Lecture 57 - Central Visual Processing Lecture 58 - Central Visual Processing and Feature Detectors Lecture 59 - Intracellular recordings from the brain - Part 1 Lecture 60 - Intracellular recordings from the brain - Part 2 Lecture 61 - Two motor systems Lecture 62 - Auditory cortex and The pattern theory of olfaction Lecture 63 - Arousal and Reticular activating system Lecture 64 - Sleep and Rapid Eye Movements Lecture 65 - Operant Conditioning by brain stimulation Lecture 66 - Hypothalamus and Feeding Behavior Lecture 67 - Brain as a gland Lecture 68 - Hypothalamic-Neurohypophyseal System Lecture 69 - Hypothalamic-Adenohypophyseal System Lecture 70 - Founding Modern Neuroanatomy Lecture 71 - Psychology and Ethology Lecture 72 - Karl Lashley Lecture 73 - Donald Hebb Lecture 74 - Limbic system-Limbic Lobe and Papez Circuit Lecture 75 - Limbic system-Kluver-Bucy Syndrome Lecture 76 - The Limbic system and Amygdala Lecture 77 - The Hippocampus and Patient H.M Lecture 78 - Brenda Milner Lecture 79 - Neurology: Foundations of Brain Imaging Lecture 80 - The Neurological unit of the Boston City Hospital Lecture 81 - Derek Denny-Brown, Raymond Adams and C. Miller Fisher Lecture 82 - Montreal Neurological Institute Lecture 83 - Cerebral Circulation Lecture 84 - Spreading depression of Leo and Migraine Lecture 85 - The Eradication of Polio Lecture 86 - Origin of Neurosurgery Lecture 87 - Harvey Cushing Lecture 88 - Pituitary Surgery Lecture 89 - Stereotaxy Lecture 90 - Epilepsy Lecture 91 - Psychosurgery Lecture 92 - Antipsychotic Drugs Lecture 93 - Reserpine Lecture 94 - Monoamine Oxidase Inhibitors Lecture 95 - Lithium Lecture 96 - Benzodiazepines Lecture 97 - Stress Lecture 98 - Theoretical Neuroscience: Brain as computer and Computer as Brain Lecture 99 - John Atanasoff Lecture 100 - John von Newmann Lecture 101 - Game and Information theory Lecture 102 - Cybernetics and Artificial Intelligence Lecture 103 - Towards Networks of Realistic Neurons: von Newman's Last word Lecture 104 - Santiago Ramon y Cajal, 'The Peasant Genius' Lecture 105 - 'Cajal- a giant wakes up' Lecture 106 - Cajal's modifications to the Golgi method and studies of embryos and various systems Lecture 107 - Law of dynamic polarization, support from others studies Lecture 108 - Santiago Ramon y Cajal - Career turning point and Palm Sunday years Lecture 109 - Cajal’s trailblazing discoveries that earned him the Nobel Prize Lecture 110 - 'Enduring Legacy of Cajal' Lecture 111 - Robert Barany - Early life and prior work done by other scientists Lecture 112 - Robert Barany - The serendipitous discovery of the caloric test Lecture 113 - Robert Barany - Vestibular System and connection to Cerebellum Lecture 114 - Robert Barany - Modern Applications of Barany's work - Space medicine and Astronaut training Lecture 115 - Robert Barany - Summary of Contributions Lecture 116 - Charles Sherrington Personal Background Lecture 117 - Charles Sherrington - quiet mind expt, Neuroplasiticity, animal locomotion studies Lecture 118 - Charles Sherrington - Reciprocal innervation, Pain and Emotion, Mind and Body Lecture 119 - Charles Sherrington's Magnum Opus - The integrative action of the nervous system Lecture 120 - Charles Sherrington - Insights into life and work by Molnar and Brown Lecture 121 - Charles Sherrington - Summary of contributions Lecture 122 - Edgar Adrian, Keith Lucas and Novel instruments used in Neurophysiology Lecture 123 - Edgar Adrian - Early life, All or none principle in neurons, Key findings with Keith Lucas Lecture 124 - Edgar Adrian - Work with Alexander Forbes, Gasser and Erlanger (St. Louis connection) Lecture 125 - Edgar Adrian - 'Failed experiment', Perseverance in science Lecture 126 - Edgar Adrian - Recording from single sensory and motor neurons Lecture 127 - Edgar Adrian - Nobel Prize, Admin work, Legacy Lecture 128 - Edgar Adrian - Adventures with EEG Lecture 129 - Edgar Adrian - Mapping cerebellar cortex, Cerebral cortex, Brain and Behavior, Olfaction Lecture 130 - Hodgkin and Huxley - Biographical background, Scientific backdrop and state of Neurophysiology Lecture 131 - Hodgkin and Huxley - Meeting of great minds and Challenges faced - Part 1 Lecture 132 - Hodgkin and Huxley - Meeting of great minds and Challenges faced - Part 2 Lecture 133 - Bernard Katz - personal background, scientific backdrop, soup vs spark debate Lecture 134 - Bernard Katz - Quantal nature of synaptic transmission, Vesicle hypothesis, foundational work Lecture 135 - Bernard Katz - del Castillo model of receptor activation, role of calcium in synapses, sodium Lecture 136 - Bernard Katz Paper: The fine structure of neuromuscular junction of the frog Lecture 137 - Roger Sperry - Personal Background, Split brain patients, Hemispheric specialization Lecture 138 - Roger Sperry: Split Brain patients and Dichotomous consciousness Lecture 139 - Roger Sperry: Unified consciousness and Behavioural differences in split brain patients, Lecture 140 - Roger Sperry, Gazzaniga's Interpreter theory, Impact on Psychology and Neuroscience, Nobel Prize Lecture 141 - Roger Sperry's Chemoaffinity hypothesis paper Lecture 142 - Roger Sperry paper 'Mentalism: Yes, Dualism:No' Lecture 143 - Jens Christian Skou Part 1 : The Story of Jens Christian Skou's life in science Lecture 144 - Jens Christian Skou: Sodium Potassium pump overview and Nobel Prize Lecture 145 - Jens Christian Skou: Paper - 'The Influence of Some Cations on an Adenosine Triphosphate Lecture 146 - Arvid Carlsson - Personal Background, Education and Early Career, Pivot, Nobel prize contributions Lecture 147 - Arvid Carlsson - History of L Dopa Lecture 148 - Arvid Carlsson - Antipsychotics, Dopamine hypothesis, Serotonin and SSRIs, Omeprazole Lecture 149 - Eric Kandel - Early life and nobel prize winning work Lecture 150 - Eric Kandel - Synaptic Plasticity Lecture 151 - Eric Kandel - Aplysia work, Short and long term memory and mechanisms Lecture 152 - Paul Greengard - The Phosphorylation Paradigm Lecture 153 - David Hubel and Torsten Wiesel - early life, education and collaboration Lecture 154 - Hubel and Wiesel - Effect of early visual deprivation on cortical function Lecture 155 - Hubel and Wiesel - Effect of visual misalignment on binocular integration Lecture 156 - Hubel and Wiesel - Limited capacity for recovery following early visual deprivation